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The signify continual-condition quantity of distribution documented for sildenafil is roughly one hundred and five L - a price which suggests the medication undergoes distribution to the tissues .
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In one-dose volunteer scientific tests of doses up to 800 mg, adverse reactions have been similar to those seen at decrease doses, although the incidence fees and severities have been amplified .
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When the NO/cGMP pathway is activated, as takes place with sexual stimulation, inhibition of PDE5 by sildenafil brings about improved corpus cavernosum levels of cGMP . Thus sexual stimulation is necessary in order for sildenafil to generate its meant advantageous pharmacological consequences .
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